Psychological health and love of life are topics that directly affect the subjective world. In this study, spiritual well-being is included in the relationship between these concepts, and the extent to which people’s inner/spiritual aspects positively affect their lives is within the scope of the research. The main purpose of this study is to examine the mediating role of spiritual well-being in the relationship between love of life and the general psychological health of individuals between the ages of 18-65. The research was designed by the Relational Screen Model. Hayes’ PROCESS Model was used to test the model’s accuracy established between dependent, independent and mediating variables. The study group of the research consists of 329 people living in various provinces of Turkey. The mediation analysis revealed that spiritual well-being partially mediated the relationship between love of life and general psychological health. Psychological health is of great importance for the individual and society. One of the most fundamental dimensions of a peaceful and healthy society is the efficiency of individuals’ communication with themselves. It is thought that general psychological health and love of life will open a new door on the path to happiness for the individual.