This study aims to investigate the relationship between fear of the COVID-19 Pandemic and psychological well-being in Turkey, by concentrating on spirituality as a moderator role. Keeping in mind Turkey’s religious and spiritual beliefs, and with the pandemic, the relationship between spirituality, fear of COVID-19 and well-being, needs to be discussed. It is hypothesized that the relationship between fear of COVID-19 and psychological well-being will be moderated by individuals’ spirituality. The survey method was used, and online data was gathered by a snowballing sample. The total of the sampling group consisted of 473 participants. In the analysis process, Process Macro v3.5 was used for moderation analysis. The findings indicate that spirituality has a moderator role on the model, especially when the spirituality of individuals’ was at a high or medium level. The results indicate that there is a moderator role of spirituality between the relationship of fear of COVID-19 and well-being, and it was so among individuals who have medium to high spirituality. The importance of the findings are discussed.